Successful Perioperative Management of Severe Bleeding From Undiagnosed Acquired Factor VIII Inhibitors.

Introduction: Acquired factor VIII (FVIII) inhibitors, also known as acquired hemophilia A, are rare with an annual incidence of 1-4 per million people [1,2]. Although the majority of cases of acquired FVIII inhibitors are idiopathic, this disorder is associated with underlying malignancies, autoimmune disease, pregnancy, infections, and medications. Bleeding complications are reported in over 80% of patients with this condition, with 9% experiencing fatal bleeding [1]. We present a case of previously undiagnosed acquired FVIII inhibitors and severe postoperative bleeding.